Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of Bicara Therapeutics Inc. (the “Company”) for the period ended June 30, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), each of the undersigned officers of the Company hereby certifies, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

1.The Report fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934, as amended; and

2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.


Date: August 12, 2025	By:	/s/ Claire Mazumdar
		Claire Mazumdar, Ph.D.
		Chief Executive Officer
		(Principal Executive Officer)

Date: August 12, 2025	By:	/s/ Ivan Hyep
		Ivan Hyep
		Chief Financial Officer
		(Principal Financial and Accounting Officer)

Bicara Therapeutics Inc. 10-Q