v3.25.4

Income Taxes - Additional information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Income Taxes
Increase (decrease) in valuation allowance	$ 38,800	$ 16,600	$ 23,800
Unrecognized income tax benefits	9,497	7,947	877	$ 289
Increase In Net Operating loss Carryforwards
Income Taxes
Increase (decrease) in valuation allowance			10,400
Full expensing of domestic research or experimental expenditures
Income Taxes
Increase (decrease) in valuation allowance	91,700
Capitalization of Research and Experimental Expenditure
Income Taxes
Increase (decrease) in valuation allowance		$ 16,400	$ 10,900
U.S. federal
Income Taxes
Operating loss carryforwards	194,500
Tax credit carryforward	10,800
State
Income Taxes
Operating loss carryforwards	275,800
Tax credit carryforward	$ 2,400

Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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Structure Therapeutics Inc. 10-K