v3.25.4

Income Taxes - Net deferred tax asset and liability (Details) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Deferred tax assets:
Net operating loss	$ 55,310	$ 26,182	$ 29,217
Capitalized research and development	36,464	33,313	16,911
Tax credits	9,580	5,054	2,631
Stock-based compensation and bonus accrual	3,386	2,433	1,737
Operating lease liability	1,241	656	1,030
Accrued expenses	2,108	1,302	1,036
Other	250	152	213
Total deferred tax assets	108,339	69,092	52,775
Less: Valuation allowance	(106,954)	(68,179)	(51,551)
Deferred tax liabilities:
Right-of-use assets	(1,139)	(487)	(960)
Property and equipment	(78)	(81)	(110)
Other	(111)	(242)	(109)
Total deferred tax liabilities	(1,328)	(810)	(1,179)
Net deferred tax assets	$ 57	$ 103	$ 45

Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from operating lease liability.

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Amount of deferred tax liability attributable to taxable temporary differences from right of use assets.

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Amount of deferred tax liability attributable to taxable temporary differences.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary difference from in-process research and development cost acquired in business combination or from joint venture formation or both.

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Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards.

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Amount, before allocation of a valuation allowances, of deferred tax assets attributable to deductible tax credit carryforwards including, but not limited to, research, foreign, general business, alternative minimum tax, and other deductible tax credit carryforwards.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from compensation and benefits costs.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from accrued liabilities.

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Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.

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Amount of deferred tax liability attributable to taxable temporary differences from property, plant, and equipment.

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Structure Therapeutics Inc. 10-K